![]() ![]() In order to show current pharmacological and/or toxicological research status on Aloe, we performed a literature search in PubMed using “Aloe” and specific country names as key words ( Table 1). A total of 1895 and 975 publications were identified when using “Aloe” as key word in All Fields Not Author and MeSH term databases, respectively. ![]() More than half (51%−60%) of these studies were conducted in the top 10 countries ( Table 1), and about one third of them are from five Asian countries, including China, India, Japan, Korea, and Iran. However, only about 8% of these articles investigated Aloe-related toxicity in vitro and in vivo ( Table 1).Īlthough Aloe vera has long been considered as a safe functional food material that can be used orally and topically, on many occasions it has not been as safe as commonly thought. Recently, the reported adverse effects in humans and toxicity, genotoxicity, and carcinogenicity in both in vitro and in vivo studies raise questions as to whether the components in Aloe vera may have tumor-promoting activities in humans.
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